A new genetic therapy that redesigns blood-forming stem cells could detect, protect and even destroy cells infected by the human immunodeficiency virus (HIV), a study published in PLOS Pathogens revealed on Friday.
The experiment carried out by scientists from the University of California, in the United States, through artificial T cells with chimeric antigen receptor that appropriates the essential interaction between HIV and the cell surface CD4 molecule, succeeded in destroying the infected cells of several monkeys and test mice, reported teleSUR on its web portal.
“These findings are the first to show that hematopoietic stem cells can be modified with a chimeric antigen receptor therapy, which can be safely grafted into the bone marrow and become functional immune cells throughout the body,” he said. study of the American university.
T cells with chimeric antigen receptor have become a powerful immunotherapy for various forms of cancer and have been a promise in the treatment of HIV.
The researchers hope that the therapy will reduce the dependence of individuals infected with antiviral drugs, reduce the cost of therapy and allow the possible eradication of HIV from the places where it is hidden in the body.